Improving the treatment of heart disease
Coronary artery disease is the most common killer in the Western world. One in four people will die from a blockage in one of the coronary arteries, preventing supply of blood and oxygen to the heart.
A common treatment for narrowed arteries is ‘Percutaneous Coronary Intervention’ or PCI, where a wire mesh tube, or ‘stent’, is inserted into the narrowed blood vessel and expanded to hold it open. The expansion of the stent compresses the abnormal build-up of atheroma narrowing the artery. This is a highly effective and relatively low risk treatment, it avoids surgery, and enables rapid improvement in the patient’s condition. Unfortunately, stents fail in 25% of patients, when the previous narrowing reoccurs within the stent.
New stents which release medication (known as ‘drug-eluting’ stents) promised a solution to this problem, with the slow local release of drugs supressing the regrowth of the tissue responsible for re-narrowing. A short-term improvement is achieved, but late failure rates still carry the risk of causing sudden death.
It is known that the presence of the stent changes blood flow, which in turn alters the growth of tissue, and thereby affects treatment outcome. Currently, there are more than 250 different stent designs available, each of which has a different effect on the 3D pattern of blood flow. The stent design is therefore critically important in determining treatment success or failure. Clinical trials with groups of patients have been unable to define the stent design features which determine success or failure due to the complexity of the problem. More detailed quantitative analysis is needed to answer the question of how different stent designs affect the complex blood flow through the coronary arteries.
This research was conducted by Susann Beier, a PhD candidate in Faculty of Medical and Health Sciences at the University of Auckland. The study aims to investigate the link between stent design features, the changes they cause in blood flow (haemodynamics), and the impact on patient outcome. Computational Fluid Dynamic (CFD) modelling was used to quantify the haemodynamics for various stent designs. This allowed the calculation of blood velocity, the stress the blood flow induces on the vessel wall, and to detect regions of rapid changes by simulating the vessel shape, circulation and blood rheology. Two commonly used stent designs were modelled to determine their respective strengths and weaknesses.
In addition to the computational simulations, a number of blood vessels were scaled up, manufactured in plastic using 3D printing and connected to a pump to simulate the heart. They were then placed in an MRI scanner to measure the blood flow with PC-MR (Phase-Contrast Magnetic Resonance). A comparison was then performed between the computational CFD and experimental MRI data with good agreement found.
Many simulation time steps were required to accurately represent the rapidly changing flow conditions in the coronaries with more than 2,500 time steps computed for a single heartbeat. To ensure full development of the flow, four heartbeats were modelled, and only the last was analysed. Each simulation contained approximately 20 million elements, and used multi-threading over six cores with 40CPU with 20GB memory each, and took around 48 hours to solve. This task would have not been possible without the use of NeSI’s Pan cluster, as the memory requirements would have exceeded local desktop capabilities well before a possibly month long solution was obtained. We were able to run many simulations on the cluster, allowing us to systematically investigate more than 20 different stent design aspects, and their impact on blood flow in the coronary arteries.
Due to having access to the Pan platform we are now extending our research to more complex vessel geometries such as vessel branching. Having gained a greater understanding of the features that are critical to idealised stent design, the next milestone is to model a stented coronary artery from an actual patient. This is a highly complex undertaking but the knowledge that can be gained will have an important impact in the treatment of patients with heart disease.
You can listen to Susann speak about her research into improving stent design with MRI here.